Naomi M. Kanof Lecturer
Jean Tang, MD/PhD, Stanford University
Better than BarbenHeimer: Clinical Trial Lessons from Rare Genetic Skin Diseases (I am Jean_Enough)
Dr. Jean Y. Tang is a Professor of Dermatology at Stanford University School of Medicine. She received her MD and PhD (Biophysics) from Stanford, completed dermatology residency at Stanford, and post-doctoral fellowship at UCSF in the laboratory of Dr. Ervin Epstein. Dr. Tang’s research focuses on rare, monogenetic skin diseases such as Basal Cell Nevus Syndrome (BCNS) and Dystrophic Epidermolysis Bullosa (RDEB). She has led or co-led the conduct and completion of 10 investigator initiated clinical trials that have been published in leading journals (NEJM, JAMA, J Clinical Oncology, Lancet Oncology). Dr. Tang and her colleagues showed that Hedgehog pathway inhibition could dramatically shrink and prevent BCCs in patients with BCNS/Gorlin Syndrome in randomized clinical trials.
She also led the investigator-initiated Phase 1/2A trials of autologous gene-therapy skin grafts for Recessive Dystrophic EB (now called EB-101, licensed to Abeona Therapeutics). The Phase 3 randomized, controlled trial of EB-101 was recently completed and EB-101 improved statistically significant wound healing and pain compared with control wounds.
Professional Education
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Internship: Santa Clara Valley Medical Center (2004) CA
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Fellowship: UCSF Dept of Epidemiology and Biostatistics (2008) CA
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Residency: Stanford University Hospital and Clinics – Dermatology Department (2007) CA
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Medical Education: Stanford University Hospital and Clinics – Dermatology Department (2003) CA
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Board Certification: American Board of Dermatology, Dermatology (2007)
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Fellow, Univ of Calif, San Francisco, KL2 Clinical Research (2009)
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Resident, Stanford University, Dermatology (2007)
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Intern, Santa Clara Valley, Medicine (2004)
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PhD, Stanford University, Biophysics (2003)
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MD, Stanford University, Medicine (2003)
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BA, UC Berkeley, Biochemistry (1995)
About the Lectureship:
Established in 1988, this award was established to honor the memory of Naomi Kanof, MD. The Naomi M. Kanof Lectureship honors an individual making significant contributions to the improvement of health through clinical research. Clinical research is broadly defined as any scientific endeavor with a direct application to improving the prevention, diagnosis, or treatment of clinical disease. This investigative work can be based in the laboratory and should be implemented or just ready to be implemented in clinical practice.