Plenary Sessions 1-3

Plenary Sessions are a showcase of submitted abstracts that the Scientific Program Chairs and organizers felt were the most representative of the most cutting edge science, reflect a diversity of topics and speakers, and was scored highly amongst the abstract reviewers (among other things).

Each Plenary Session will run for one hour in length and will offer both a ten (10) minute presentation and a two (2) minute Q&A period immediately after.

Plenary Session # 1, Thursday, May 19, 2022, 1:45 pm – 2:45 pm, Oregon Ballroom 201/202

1:45 pm.

Abstract # 082.  In vivo tracking of clonal dynamics shows three phases of UV-induced skin carcinogenesis

S. Avdieiev^{1, 2}, L. Tordesillas³, O. Chavez Chiang³, Z. Chen⁴, L. Silva Simoes², Y. Chen⁴, N. Andor², R. Gatenby^{1, 2}, E. Flores⁵, J. Brown^{1, 2}, K. Y. Tsai^{1, 3}

¹Cancer Biology and Evolution Program, Moffitt Cancer Center, Tampa, Florida, United States, ²Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida, United States, ³Tumor Biology Department, Moffitt Cancer Center, Tampa, Florida, United States, ⁴Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States, ⁵Department of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida, United States

1:57 pm.

Abstract # 125.  Dermal adipocyte precursor immune fibroblastic cells (IFCs) drive neutrophil recruitment in response to bacterial infection

K. Cavagnero, T. Dokoshi, A. O’Neill, J. Seidman, M. Liggins, R. Gallo

Dermatology, University of California San Diego, La Jolla, California, United States

2:09 pm.

Abstract # 299.  Oral difelikefalin improves itch and inflammatory biomarkers in atopic dermatitis subjects with moderate-to-severe pruritus

E. Guttman-Yassky¹, P. Facheris^{1, 2}, J. Correa Da Rosa¹, E. Del Duca¹, Y. Estrada¹, E. David¹, A. Pavel³, S. Bose¹, J. Goncalves⁴, K. Nograles⁴, B. Kim¹, M. Lebwohl¹

¹Icahn School of Medicine at Mount Sinai, New York, New York, United States, ²Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy, ³The University of Mississippi, University, Mississippi, United States, ⁴Cara Therapeutics, Inc., Stamford, Massachusetts, United States

2:21 pm.

Abstract # 480.  The spectrum of oligogenic variants in the RAS pathway in a PHACE cohort

D. Siegel¹, E. Partan³, O. Davies⁹, S. Chamlin², B. Drolet⁴, A. Mancini², L. Sundaram¹, M. Tutaj⁸, I. Frieden⁵, D. Metry⁶, F. Blei⁷, C. Lin⁸, K. Wang¹, I. Karakikes¹, A. Urban¹, A. Oro¹, N. Sobreira³

¹Stanford University School of Medicine, Stanford, California, United States, ²Ann and Robert H Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States, ³Johns Hopkins Medicine, Baltimore, Maryland, United States, ⁴University of Wisconsin-Madison, Madison, Wisconsin, United States, ⁵University of California San Francisco School of Medicine, San Francisco, California, United States, ⁶Baylor College of Medicine, Houston, Texas, United States, ⁷NYU Langone Health, New York, New York, United States, ⁸Medical College of Wisconsin, Milwaukee, Wisconsin, United States, ⁹Harvard Medical School, Boston, Massachusetts, United States

2:33 pm.

Abstract # 544.  Commensal induced accumulation of monocyte-derived cells in neonatal skin regulates long-term cutaneous type 17 inflammation.

M. Dhariwala, J. Okoro, T. Scharschmidt

Dermatology, University of California San Francisco, San Francisco, California, United States

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Plenary Session # 2, Friday, May 20, 2022, 1:45 pm – 2:45 pm, Oregon Ballroom 201/202

1:45 pm.

Abstract # 012.  Tissue-specific manipulation of regulatory T cells reveals the skin to be a site of immune tolerance

J. Cohen¹, J. Moreau², V. Gouirand², C. Macon², I. Boothby², I. Gratz³, A. Stoecklinger³, C. Weaver⁴, A. Sharpe⁵, R. Ricardo-Gonzalez², M. Rosenblum²

¹Dermatopathology, University of California San Francisco, San Francisco, California, United States, ²Dermatology, University of California San Francisco, San Francisco, California, United States, ³Universitat Salzburg Naturwissenschaftliche Fakultat, Salzburg, Salzburg, Austria, ⁴The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States, ⁵Harvard Medical School, Boston, Massachusetts, United States

1:57 pm.

Abstract # 140.  Dissecting the cellular landscape of human skin across anatomical sites and in cutaneous malignancy through single cell transcriptomics and in situ sequencing

C. Ganier¹, N. Harun¹, F. M. Watt¹, M. D. Lynch^{1, 2}

¹King’s College London, London, United Kingdom, ²St John’s Institute of Dermatology, London, United Kingdom

2:09 pm.

Abstract # 195.  Cutaneous toxicities associated with immune checkpoint inhibitors: an observational, pharmacovigilance study

T. Le¹, I. Brown¹, M. Taylor¹, J. Deng¹, V. Parthasarathy¹, Z. A. Bordeaux¹, M. P. Alphonse¹, J. Alhariri¹, S. Kang¹, Y. Semenov², S. G. Kwatra¹

¹Department of Dermatology, Johns Hopkins Medicine, Baltimore, Maryland, United States, ²Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, United States

2:21 pm.

Abstract # 501.  Meta-analyses of genome-wide association studies in multiethnic cohorts identify risk loci associated with hidradenitis suppurativa

H. Choquet¹, J. Yin¹, Y. Kim², T. Hoffmann³, S. Saini⁴, S. Shringarpure⁴, 2. Team⁴, E. Jorgenson⁵, M. M. Asgari²

¹Division of Research, Kaiser Permanente Northern California, Oakland, California, United States, ²Department of Dermatology, Massachusetts General Hospital, Boston, Maryland, United States, ³Institute for human Genetics, University of California San Francisco, UCSF, San Francisco, California, United States, ⁴23andMe, Sunnyvale, California, United States, ⁵Regeneron Genetics Center, Tarrytown, New York, United States

2:33 pm.

Abstract # 678.  Efficacy of topical LXR agonist in the treatment of primary cicatricial alopecia in Scd1^−/− mouse

J. Kim¹, J. Huang¹, E. Wang¹, A. M. Christiano^{1, 2}

¹Department of Dermatology, Columbia University, New York, New York, United States, ²Department of Genetics and Development, Columbia University, New York, New York, United States

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Plenary Session # 3, Saturday, May 21, 2022, 8:30 am – 9:30 am, Oregon Ballroom 201/202

8:30 am.

Abstract # 419.  Glucose controls protein-protein interactions and epidermal differentiation

V. Lopez-Pajares¹, A. Bhaduri², Y. Zhao¹, G. Gowrishankar¹, L. Donohue¹, M. Guo¹, A. Guerrero³, A. Ji¹, O. Garcia¹, S. Gambir¹, P. Khavari^{1, 4}

¹Stanford University, Stanford, California, United States, ²University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, United States, ³UPMC, Pittsburgh, Pennsylvania, United States, ⁴VA Palo Alto Health Care System, Palo Alto, California, United States

8:42 am.

Abstract # 635.  Reprogramming the tumor microenvironment by a second-generation recombinant modified vaccinia virus Ankara

S. Liu¹, G. Mazo¹, N. Yang¹, T. Zhang², S. B. Tariq¹, Y. Wang¹, D. Hirschhorn-Cymerman¹, L. Ji¹, A. Tan², J. Wang³, W. Yan⁴, J. Choi⁴, A. Rossi¹, J. Z. Xiang², M. O. Li¹, T. Merghoub¹, J. D. Wolchok¹, L. Deng¹

¹Memorial Sloan Kettering Cancer Center, New York, New York, United States, ²Weill Cornell Medicine, New York, New York, United States, ³Genvira Biosciences, Ottawa, Ontario, Canada, ⁴IMVAQ Therapeutics, Sammamish, Washington, United States

8:54 am.

Abstract # 741.  Structural adaptations of epidermal stem cells to mechanical stress

S. Huang, G. Rice, P. Rompolas

Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States

9:06 am.

Abstract # 760.  Cellular landscape of the skin is primed by the oral epithelial regenerative transcription factor Pitx1 to promote wound healing

A. Overmiller, A. Uchiyama, E. Hope, A. Sawaya, S. Nayak, K. Hasneen, S. Dell’Orso, S. Brooks, M. Morasso

NIAMS, National Institutes of Health, Bethesda, Maryland, United States

9:18 am.

Abstract # 804. Fibroblast subpopulations orchestrate chronic inflammation in Hidradenitis Suppurativa

K. R. van Straalen¹, F. Ma², O. Plazyo¹, M. Calbet⁴, X. Xing¹, M. Gharaee-Kermani^{1, 2}, P. W. Harms^{1, 3}, R. Wasikowski¹, L. Nahlawi¹, A. Billi¹, J. Kahlenberg², E. Maverakis⁵, L. C. Tsoi¹, J. E. Gudjonsson¹

¹Dept of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, United States, ²Div of Rheumatology, Dept of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States, ³Dept of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States, ⁴R&D Center, Almirall SA, Sant Feliu de Llobregat, Barcelona, Spain, ⁵Dept of Dermatology, University of California, Sacramento, California, United States